KIT ELISA Kit for Human(Homo sapiens) | EIAab.comKIT ELISA Kit for Human(Homo sapiens)

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Index > Protein center > KIT(Gene name) > Human

KIT (Gene name),

Mast/stem cell growth factor receptor Kit (Protein name ), KIT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KIT(SCFR);

Protein name:

Mast/stem cell growth factor receptor Kit(SCFR);

Alternative:

Proto-oncogene c-Kit;Piebald trait protein(PBT);p145 c-kit;Tyrosine-protein kinase Kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;

CD:

CD117;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with PIK3R1 and PIK3CD. Interacts (via phosphorylated tyrosine) with CRK (isoform Crk-II), FYN, SHC1 and MATK/CHK (via SH2 domain). Interacts with LYN and FES/FPS. Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU. Interacts with PLCG1.

Function:

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

Subcellular Location:

Isoform 3 Cytoplasm Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.

Protein Attributes:

Sequence length:

976

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

976:

VDHSVRINSV | GSTASSSQPL | LVHDDV

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

KEGG:

hsa:3815

MIM:

164920

STRING:

9606.ENSP00000288135

Pfam:

PF00047

String:

P10721

UniGene:

Hs.479754

SMR:

P10721

Uniprot:

P10721

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ELISA Kit for Human SCFR

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E0121m

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96T

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ELISA Kit for Human SCFR

Cat.:

E0121h

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96T

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ELISA Kit for Human SCFR

Cat.:

E0121b

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96T

ELISA Kit for Human SCFR

Cat.:

E0121d

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96T

ELISA Kit for Human SCFR

Cat.:

E0121p

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96T

ELISA Kit for Human SCFR

Cat.:

E0121c

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96T

CLIA Kit for Human SCFR

Cat.:

U0121c

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96T

CLIA Kit for Human SCFR

Cat.:

U0121d

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96T

CLIA Kit for Human SCFR

Cat.:

U0121p

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96T

CLIA Kit for Human SCFR

Cat.:

U0121b

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96T

CLIA Kit for Human SCFR

Cat.:

U0121h

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Manual:

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96T

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CLIA Kit for Human SCFR

Cat.:

U0121m

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96T

Polyclonal Antibody for Human SCFR

Cat.:

P0121Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human SCFR

Cat.:

P0121Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human SCFR

Monoclonal Antibody for Human SCFR

Protein for Human SCFR

Cat.:

R0121h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human SCFR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand."
Yarden Y. , Kuang W.-J. , Yang-Feng T. , Coussens L. , Munemitsu S. , Dull T.J. , Chen E. , Schlessinger J. , Francke U. , Ullrich A.
EMBO J.6:3341-3351(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Fetal brain.
tissue: Term placenta.
2.

"Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene."
Giebel L.B. , Strunk K.M. , Holmes S.A. , Spritz R.A.
Oncogene7:2207-2217(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
3.

"Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes."
Andre C. , Hampe A. , Lachaume P. , Martin E. , Wang X.P. , Manus V. , Hu W.X. , Galibert F.
Genomics39:216-226(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
Jin P. , Zhang J. , Sumariwalla P.F. , Ni I. , Jorgensen B. , Crawford D. , Phillips S. , Feldmann M. , Shepard H.M. , Paleolog E.M.
Arthritis Res. Ther.10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
5.

"Retinoic acid enhances sensitivity of neuroblastoma cells for imatinib mesylate."
Neumann I. , Foell J.L. , Bremer M. , Volkmer I. , Korholz D. , Burdach S. , Staege M.S.
Pediatr. Blood Cancer55:464-470(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;INDUCTION
6.

"Sequence of KIT mRNA from all-trans retinoic acid treated neuroblastoma cell lines."
Staege M.S. , Neumann I. , Volkmer I.
Submitted (2010-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Trachea.
8.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
10.

"Characterization of the promoter region of the human c-kit proto-oncogene."
Yamamoto K. , Tojo A. , Aoki N. , Shibuya M.
Jpn. J. Cancer Res.84:1136-1144(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
11.

"Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C."
Blume-Jensen P. , Ronnstrand L. , Gout I. , Waterfield M.D. , Heldin C.H.
J. Biol. Chem.269:21793-21802(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PIK3R1; RAF1 AND MAPK1;INTERACTION WITH GRB2; PIK3R1 AND PIK3 CATALYTIC SUBUNIT;ENZYME REGULATION;PHOSPHORYLATION
12.

"Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells."
Blume-Jensen P. , Wernstedt C. , Heldin C.H. , Ronnstrand L.
J. Biol. Chem.270:14192-14200(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-741; SER-746; SER-821 AND SER-959;ENZYME REGULATION;PARTIAL PROTEIN SEQUENCE;MUTAGENESIS OF SER-741 AND SER-746
13.

"Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes."
Price D.J. , Rivnay B. , Fu Y. , Jiang S. , Avraham S. , Avraham H.
J. Biol. Chem.272:5915-5920(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1; MATK/CHK; FYN AND SHC1;PHOSPHORYLATION AT TYR-568; TYR-570 AND TYR-721
14.

"Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells."
Linnekin D. , DeBerry C.S. , Mou S.
J. Biol. Chem.272:27450-27455(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN
15.

"SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain."
Kozlowski M. , Larose L. , Lee F. , Le D.M. , Rottapel R. , Siminovitch K.A.
Mol. Cell. Biol.18:2089-2099(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN6;AUTOPHOSPHORYLATION;FUNCTION IN PHOSPHORYLATION OF PTPN6
16.

"Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor."
Thommes K. , Lennartsson J. , Carlberg M. , Ronnstrand L.
Biochem. J.341:211-216(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2 AND GRB7;PARTIAL PROTEIN SEQUENCE;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-703 AND TYR-936
17.

"The receptor protein tyrosine phosphatase, PTP-RO, is upregulated during megakaryocyte differentiation and is associated with the c-Kit receptor."
Taniguchi Y. , London R. , Schinkmann K. , Jiang S. , Avraham H.
Blood94:539-549(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRU;FUNCTION IN PHOSPHORYLATION OF PTPRU
18.

"The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity."
Mancini A. , Koch A. , Stefan M. , Niemann H. , Tamura T.
FEBS Lett.482:54-58(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MPDZ;CHARACTERIZATION OF VARIANT VAL-816;MUTAGENESIS OF LYS-623
19.

"Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling."
Liang X. , Wisniewski D. , Strife A. , Shivakrupa R. , Clarkson B. , Resh M.D.
J. Biol. Chem.277:13732-13738(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN; TEC AND DOK1
20.

"The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit."
Wollberg P. , Lennartsson J. , Gottfridsson E. , Yoshimura A. , Ronnstrand L.
Biochem. J.370:1033-1038(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2B2/APS;FUNCTION IN PHOSPHORYLATION OF SH2B2/APS;MUTAGENESIS OF ILE-571 AND LEU-939
21.

"Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk."
Lennartsson J. , Wernstedt C. , Engstrom U. , Hellman U. , Ronnstrand L.
Exp. Cell Res.288:110-118(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-891 AND TYR-900;PARTIAL PROTEIN SEQUENCE;INTERACTION WITH CRK AND PIK3R1;FUNCTION IN PHOSPHORYLATION OF CRK; AKT1 AND MAP KINASES;IDENTIFICATION BY MASS SPECTROMETRY
22.

"Src family kinases are involved in the differential signaling from two splice forms of c-Kit."
Voytyuk O. , Lennartsson J. , Mogi A. , Caruana G. , Courtneidge S. , Ashman L.K. , Ronnstrand L.
J. Biol. Chem.278:9159-9166(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ALTERNATIVE SPLICING
23.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-130
tissue: Plasma.
24.

"The tyrosine kinase FES is an essential effector of KITD816V proliferation signal."
Voisset E. , Lopez S. , Dubreuil P. , De Sepulveda P.
Blood110:2593-2599(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FES/FPS;CHARACTERIZATION OF VARIANT VAL-816
25.

"Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl."
Sun J. , Pedersen M. , Bengtsson S. , Ronnstrand L.
Exp. Cell Res.313:3935-3942(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2 AND CBL;UBIQUITINATION;FUNCTION IN PHOSPHORYLATION OF CBL
26.

"The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction."
Sun J. , Pedersen M. , Ronnstrand L.
J. Biol. Chem.284:11039-11047(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF SIGNALING PATHWAYS AND CELL SURVIVAL;FUNCTION IN PHOSPHORYLATION OF CBL;PHOSPHORYLATION AT TYR-568; TYR-703; TYR-721 AND TYR-936;UBIQUITINATION;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANT VAL-816
27.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-959;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.

"Expression of a truncated form of KIT tyrosine kinase in human spermatozoa correlates with sperm DNA integrity."
Muciaccia B. , Sette C. , Paronetto M.P. , Barchi M. , Pensini S. , D'Agostino A. , Gandini L. , Geremia R. , Stefanini M. , Rossi P.
Hum. Reprod.25:2188-2202(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
29.

"Function of activation loop tyrosine phosphorylation in the mechanism of c-Kit auto-activation and its implication in sunitinib resistance."
DiNitto J.P. , Deshmukh G.D. , Zhang Y. , Jacques S.L. , Coli R. , Worrall J.W. , Diehl W. , English J.M. , Wu J.C.
J. Biochem.147:601-609(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-547; TYR-553; TYR-703; TYR-721; TYR-730; TYR-823 AND TYR-900;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF TYR-823;CHARACTERIZATION OF VARIANT HIS-816
30.

"Mechanism of activation of human c-KIT kinase by internal tandem duplications of the juxtamembrane domain and point mutations at aspartic acid 816."
Kim S.Y. , Kang J.J. , Lee H.H. , Kang J.J. , Kim B. , Kim C.G. , Park T.K. , Kang H.
Biochem. Biophys. Res. Commun.410:224-228(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;AUTOPHOSPHORYLATION;SUBUNIT;CHARACTERIZATION OF VARIANT VAL-816
31.

"Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells."
Chaix A. , Lopez S. , Voisset E. , Gros L. , Dubreuil P. , De Sepulveda P.
J. Biol. Chem.286:5956-5966(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION AND PHOSPHORYLATION OF STAT1; STAT3; STAT5A AND STAT5B
32.

"Signal transduction via the stem cell factor receptor/c-Kit."
Ronnstrand L.
Cell. Mol. Life Sci.61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
33.

"Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor."
Roskoski R. Jr.
Biochem. Biophys. Res. Commun.337:1-13(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON KIT SIGNALING
34.

"Normal and oncogenic forms of the receptor tyrosine kinase kit."
Lennartsson J. , Jelacic T. , Linnekin D. , Shivakrupa R.
Stem Cells23:16-43(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
35.

"Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway."
Kent D. , Copley M. , Benz C. , Dykstra B. , Bowie M. , Eaves C.
Clin. Cancer Res.14:1926-1930(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
36.

"Tumor-intrinsic and -extrinsic roles of c-Kit: mast cells as the primary off-target of tyrosine kinase inhibitors."
Pittoni P. , Piconese S. , Tripodo C. , Colombo M.P.
Oncogene30:757-769(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
37.

"Structure of a c-kit product complex reveals the basis for kinase transactivation."
Mol C.D. , Lim K.B. , Sridhar V. , Zou H. , Chien E.Y. , Sang B.C. , Nowakowski J. , Kassel D.B. , Cronin C.N. , McRee D.E.
J. Biol. Chem.278:31461-31464(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 549-931 IN COMPLEX WITH ADP AND MAGNESIUM IONS;SUBUNIT;PHOSPHORYLATION AT TYR-568 AND TYR-570;IDENTIFICATION BY MASS SPECTROMETRY
38.

"Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase."
Mol C.D. , Dougan D.R. , Schneider T.R. , Skene R.J. , Kraus M.L. , Scheibe D.N. , Snell G.P. , Zou H. , Sang B.C. , Wilson K.P.
J. Biol. Chem.279:31655-31663(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 565-935 IN COMPLEXES WITH INHIBITOR IMATINIB AND PHOSPHATE;ENZYME REGULATION
39.

"Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor."
Yuzawa S. , Opatowsky Y. , Zhang Z. , Mandiyan V. , Lax I. , Schlessinger J.
Cell130:323-334(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 1-519 IN COMPLEX WITH KITLG/SCF;INTERACTION WITH KITLG/SCF;SUBUNIT;DISULFIDE BONDS;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;MUTAGENESIS OF ARG-381 AND GLU-386;GLYCOSYLATION AT ASN-130; ASN-283; ASN-293; ASN-300; ASN-320; ASN-352 AND ASN-367
40.

"KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients."
Gajiwala K.S. , Wu J.C. , Christensen J. , Deshmukh G.D. , Diehl W. , DiNitto J.P. , English J.M. , Greig M.J. , He Y.A. , Jacques S.L. , Lunney E.A. , McTigue M. , Molina D. , Quenzer T. , Wells P.A. , Yu X. , Zhang Y. , Zou A. , more...
Proc. Natl. Acad. Sci. U.S.A.106:1542-1547(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 544-935 IN COMPLEX WITH SUNITINIB;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;CHARACTERIZATION OF VARIANTS HIS-816 AND VAL-816;ENZYME REGULATION
41.

"Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase."
Zadjali F. , Pike A.C. , Vesterlund M. , Sun J. , Wu C. , Li S.S. , Ronnstrand L. , Knapp S. , Bullock A.N. , Flores-Morales A.
J. Biol. Chem.286:480-490(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 564-574 IN COMPLEX WITH SOCS6;PHOSPHORYLATION AT TYR-568
42.

"Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene."
Fleischman R.A.
J. Clin. Invest.89:1713-1717(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PBT LYS-583
43.

"Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism."
Spritz R.A. , Giebel L.B. , Holmes S.A.
Am. J. Hum. Genet.50:261-269(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PBT LEU-584
44.

"Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism."
Giebel L.B. , Spritz R.A.
Proc. Natl. Acad. Sci. U.S.A.88:8696-8699(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PBT ARG-664
45.

"Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product."
Furitsu T. , Tsujimura T. , Tono T. , Ikeda H. , Kitayama H. , Koshimizu U. , Sugahara H. , Butterfield J.H. , Ashman L.K. , Kanayama Y. , Matsuzawa Y. , Kitamura Y. , Kanakura Y.
J. Clin. Invest.92:1736-1744(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MAST CELL LEUKEMIA VAL-816
46.

"Novel mutations of the KIT (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism."
Spritz R.A. , Holmes S.A. , Itin P. , Kuester W.
J. Invest. Dermatol.101:22-25(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PBT GLY-791 AND VAL-812
47.

"A 12-bp deletion (7818del12) in the c-kit protooncogene in a large Italian kindred with piebaldism."
Riva P. , Milani N. , Gandolfi P. , Larizza L.
Hum. Mutat.6:343-345(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PBT 893-GLU--PRO-896 DEL
48.

"A new c-kit mutation in a case of aggressive mast cell disease."
Pignon J.-M. , Giraudier S. , Duquesnoy P. , Jouault H. , Imbert M. , Vainchenker W. , Vernant J.-P. , Tulliez M.
Br. J. Haematol.96:374-376(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MAST CELL DISEASE GLY-820
49.

"Piebaldism with deafness: molecular evidence for an expanded syndrome."
Spritz R.A. , Beighton P.
Am. J. Med. Genet.75:101-103(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PBT GLY-796
50.

"c-kit activating mutations and mast cell proliferation in human leukemia."
Beghini A. , Larizza L. , Cairoli R. , Morra E.
Blood92:701-702(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ACUTE MYELOID LEUKEMIA TYR-816
51.

"A novel KIT gene missense mutation in a Japanese family with piebaldism."
Nomura K. , Hatayama I. , Narita T. , Kaneko T. , Shiraishi M.
J. Invest. Dermatol.111:337-338(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PBT PRO-847
52.

"Familial gastrointestinal stromal tumours with germline mutation of the KIT gene."
Nishida T. , Hirota S. , Taniguchi M. , Hashimoto K. , Isozaki K. , Nakamura H. , Kanakura Y. , Tanaka T. , Takabayashi A. , Matsuda H. , Kitamura Y.
Nat. Genet.19:323-324(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GIST VAL-559 DEL
53.

"Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors."
Hirota S. , Isozaki K. , Moriyama Y. , Hashimoto K. , Nishida T. , Ishiguro S. , Kawano K. , Hanada M. , Kurata A. , Takeda M. , Muhammad Tunio G. , Matsuzawa Y. , Kanakura Y. , Shinomura Y. , Kitamura Y.
Science279:577-580(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GIST ILE-550; 550-LYS--LYS-558 DEL; 551-PRO--VAL-555 DEL; ASP-559 AND 559-VAL-VAL-560 DEL
54.

"Activating c-kit gene mutations in human germ cell tumors."
Tian Q. , Frierson H.F. Jr. , Krystal G.W. , Moskaluk C.A.
Am. J. Pathol.154:1643-1647(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-816;CHARACTERIZATION OF VARIANT HIS-816
55.

"Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis."
Longley B.J. Jr. , Metcalfe D.D. , Tharp M. , Wang X. , Tyrrell L. , Lu S.-Z. , Heitjan D. , Ma Y.
Proc. Natl. Acad. Sci. U.S.A.96:1609-1614(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MASTOCYTOSIS VAL-816; PHE-816; TYR-816 AND LYS-839;CHARACTERIZATION OF VARIANTS MASTOCYTOSIS VAL-816; PHE-816; TYR-816 AND LYS-839
56.

"Three novel mutations of the proto-oncogene KIT cause human piebaldism."
Syrris P. , Malik N.M. , Murday V.A. , Patton M.A. , Carter N.D. , Hughes H.E. , Metcalfe K.
Am. J. Med. Genet.95:79-81(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PBT CYS-584; ARG-601 AND PRO-656
57.

"Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa."
Beghini A. , Tibiletti M.G. , Roversi G. , Chiaravalli A.M. , Serio G. , Capella C. , Larizza L.
Cancer92:657-662(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GIST ALA-559
58.

"A mutation-created novel intra-exonic pre-mRNA splice site causes constitutive activation of KIT in human gastrointestinal stromal tumors."
Chen L.L. , Sabripour M. , Wu E.F. , Prieto V.G. , Fuller G.N. , Frazier M.L.
Oncogene24:4271-4280(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GIST 550-LYS--LYS-558 DEL
59.

"Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults."
Bignell G. , Smith R. , Hunter C. , Stephens P. , Davies H. , Greenman C. , Teague J. , Butler A. , Edkins S. , Stevens C. , O'meara S. , Parker A. , Avis T. , Barthorpe S. , Brackenbury L. , Buck G. , Clements J. , Cole J. , more...
Genes Chromosomes Cancer45:42-46(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TYR-816; LYS-822 AND PRO-829
60.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-532; LEU-541; SER-691; ASN-715; ASN-737; TRP-804; TYR-816; LYS-822 AND PRO-829

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